A total of 500 faecal samples were collected from apparently healthy FUTA students to determine the carrier rate of Esherichia coli O157:H7, the aetiological cause of enterohemorrhagic diarrhoea using standard microbiological and serological methods. The antibiogram and plasmid profiles were also determined using standard methods. Twenty-nine (5.8%) of the sampled examined were positive for E. coli with highest frequency of occurrence in males and age group, 20-24 years. The isolates were resistant to most of the convectional antibiotics used except Ofloxacin and Ciprofloxacin. Twelve (41.4%) of the isolates showed multi- drug resistance to three or more antibiotics group while the size of the plasmids isolated ranged from 23,130 - 34,637 bp. With the high incidence of carriage of E. coli O157:H7 observed in this study, there is need to set up national surveillance programs in order to prevent epidemiological outbreak of infections and complications caused by this organism, more so that the organism exhibited multiple resistance to common antibiotics.
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