FUTA JOURNAL OF RESEARCH IN SCIENCE

VOLUME 11 NUMBER 1 2015

Paper Details

  • Title :INFLUENCE OF HAEMOGLOBIN GENOTYPE ON MALARIA PARASITE DENSITY AND ANTI-MSP-119 IGG (ANTIBODY) RESPONSE IN PREGNANT WOMEN AND BIRTH WEIGHT OF NEONATES
  • Author(s) : O.M. Akanbi
  • Abstract:

Haemoglobin genotype variance has been reported to be responsible for the high susceptibility of individuals to
malaria in the tropics. This study assessed the influence of haemoglobin genotype on the malaria parasite density
and anti-MSP-119 IgG (antibody) during pregnancy and the effect of malaria infection on birth weight of neonates.
One hundred and thirty (130) pregnant women and one hundred and fourteen (114) non-pregnant women (Control)
were enrolled and grouped according to their haemoglobin genotype. The study assessed only the pregnant women
with haemoglobin genotype AA (HbAA) and haemoglobin genotype AS (HbAS). Blood sample from each subject
was collected by venipuncture into EDTA, and plain bottles to determine haematological parameters and anti-MSP-
119 IgG (antibody) level, respectively. The parasite density was significantly higher (P<0.05) in malaria positive
HbAA women than in malaria positive HbAS women in dry and wet seasons. There was a significant increase
(P<0.05) in the mean anti-MSP-119 IgG (antibody) levels in women with HbAA as compared with women with
HbAS in the dry season. The anti-MSP-119 IgG level was not significantly higher in women with HbAA when
compared with women with HbAS. The mean birth weight of neonates born to malaria positive HbAA women was
lower than those born to malaria positive HbAS women in the wet season, but there was no significant difference
between the mean birth weight of neonates born to malaria positive and malaria negative HbAA and HbAS women
in dry season. This study showed that haemoglobin genotype influenced parasite density but did not influence the
level of anti-MSP-119 IgG and the birth weight of neonates.
Keywords: Haemoglobin genotype, malaria parasite, anti-MSP-119 IgG, pregnant women